Sunday, September 6, 2009

Children's Coma Scale (Modified Glasgow Coma Scale, Adelaide Coma Scale, Paediatric Coma Scale)

Overview :

One of the components of the Glasgow coma scale is the best verbal response, which cannot be assessed in nonverbal small children. A modification of the original Glasgow coma scale was created for children too young to talk.

Parameters:

(1) eyes opening

(2) best verbal or nonverbal response (depending on development status)

(3) best motor response

Eye OpeningScore
spontaneously4
to verbal stimuli3
to pain2
never1

Nonverbal Child

Verbal Child's Best Verbal Response (Glasgow coma scale)

Score

smiles, oriented to sound, follows objects, interacts

oriented and converses

5

consolable when crying and interacts inappropriately

disoriented and converses

4

inconsistently consolable and moans; makes vocal sounds

inappropriate words

3

inconsolable, irritable and restless; cries

incomprehensible sounds

2
no responseno response1
Best Motor ResponseScore
obeys command6
localizes pain5
flexion withdrawal4
abnormal flexion (decorticate rigidity)3
extension (decerebrate rigidity)2
no response1

Additional markers associated with prognosis:

(1) oculovestibular reflex (all children with absent reflexes died; 50% of children with impaired reflex died; 25% with normal reflexes died)

(2) abnormal pupillary response (77% with bilateral fixed and dilated pupils died)

(3) intracranial pressure (pressures > 40 torr with CCS scores of 3, 4 or 5 was inevitably fatal)

children's coma scale =

= (score for eye opening) + (score for best nonverbal or verbal response) + (score for best motor response)

Interpretation:

• minimum score is 3, which has the worst prognosis

• maximum score is 15, which has the best prognosis

• Scores of 7 or above have a good chance for recovery.

• Scores of 3-5 are potentially fatal, especially if accompanied by fixed pupils or absent oculovestibular responses or elevated intracranial pressure.

• Normal children under 5 years may have lower scores than adults because of reduced best verbal and motor responses.

Experiment 3

Hormone or Metabolites

Enzyme activity change

Blood Glucose

Elevated insulin

Glucose 6 phosphatase decrease

Glucokinase increase

decrease


decrease

Elevated glucose 6-P

glycogen synthase D increase

decrease

Elevated glucagon

adenylate cyclase increase

increase

Elevated epinephrine

adenylate cyclase increase

increase

elevated cyclic AMP

Protein kinase increase

increase

Cases

Sept 11- Mannosidosis

Sept 18- Von Gierke's Diseases

Sept 25- Diabetes Mellitus and Obesity